Evaluation of Drug Release from Carboxymethyl Starch-Xanthan Gum-HPMC Matrix

The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been focus current research activity in design matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, used matrices investigate release behavior drug. In order enrich resources, there is a quest for new polysaccharide owing diverse chemical composition functional groups are amenable modification thus tailor made polymeric obtained which can be modulate oral drug release. objective study characterize Verapamil hydrochloride loaded dosage form using hydroxy xanthan corn starch rate retarding polymer. Dosage forms were prepared different along with hydrochloride. Carboxymethylation was performed. Drug evaluated simulated gastric media. Addition gum significantly retarded burse retardation found dependent upon concentration. formulation composed HPMC K4M CS (ARI-ARI3) followed super case transport swelling controlled, purely relaxation controlled delivery.
 Keywords: HCl, Natural gums, HPMC, sustained